A three gene immunohistochemical panel serves as an adjunct to clinical staging of patients with head and neck cancer
作者：Chin‐Ann Johnny Ong, Nicholas B. Shannon, Stefan C. Mueller, Sze Min Lek, Xuan Qiu, Fui Teen Chong, Ke Li, Kelvin K.N. Koh, Gerald Tay, Thakshayeni Skanthakumar, Jacqueline Siok Gek Hwang, Tony Kiat Hon Lim, Mei‐Kim Ang, Daniel Shao-Weng Tan, Ngian‐Chye Tan, Hiang Khoon Tan, Khee Chee Soo, N. Gopalakrishna Iyer · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.18568 · 被引用次数：13 · 研究领域：Head and Neck Cancer Studies、Cancer-related gene regulation、RNA modifications and cancer
// Chin-Ann J. Ong 1, 3, * , Nicholas B. Shannon 2, * , Stefan Mueller 3, 7, * , Sze Min Lek 2, * , Xuan Qiu 1 , Fui Teen Chong 4 , Ke Li 2 , Kelvin K.N. Koh 2 , Gerald C.A. Tay 1, 7 , Thakshayeni Skanthakumar 3 , Jacqueline S.G. Hwang 5 , Tony Kiat Hon Lim 5 , Mei Kim Ang 6 , Daniel S.W. Tan 6 , Ngian-Chye Tan 7 , Hiang Khoon Tan 7 , Khee Chee Soo 7 and N. Gopalakrishna Iyer 2, 4, 7 1 Department of General Surgery, Singapore General Hospital, S169856, Singapore 2 Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, S169857, Singapore 3 Division of Surgical Oncology, National Cancer Centre, S169610, Singapore 4 Cancer Therapeutics Research Laboratory, National Cancer Centre, S169610, Singapore 5 Department of Anatomical Pathology, Singapore General Hospital, S169856, Singapore 6 Department of Medical Oncology, National Cancer Centre, S169610, Singapore 7 Singhealth Duke-NUS Head and Neck Centre, Singhealth, S169856, Singapore * These authors contributed equally to this work Correspondence to: N. Gopalakrishna Iyer, email: gopaliyer@nccs.com.sg Keywords: head and neck squamous cell carcinoma, immunohistochemistry, genomics Received: February 21, 2017 Accepted: June 08, 2017 Published: June 19, 2017 ABSTRACT Background: Current management of head and neck squamous cell carcinoma (HNSCC) depends on tumor staging. Despite refinements in clinical staging algorithms, outcomes remain unchanged for the last two de...