MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin

作者：Bo Wu, Xiaoqi Li, Tong Huang, Shuting Lu, Bing Wan, Rufang Liao, Yushuang Li, Aju Baidya, Qingyun Long, Haibo Xu · 发表于：Biomaterials Science · 年份：2017 · DOI：10.1039/c7bm00431a · 被引用次数：32 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Porphyrin and Phthalocyanine Chemistry

Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd(iii)). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance.