Association of keratin 8/18 variants with non-alcoholic fatty liver disease and insulin resistance in Chinese patients: A case-control study

作者：Rui Li, Xianhua Liao, Junzhao Ye, Min-Rui Li, Yanqin Wu, Xuan Hu, Bihui Zhong · 发表于：World Journal of Gastroenterology · 年份：2017 · DOI：10.3748/wjg.v23.i22.4047 · 被引用次数：20 · 研究领域：Skin and Cellular Biology Research、Hair Growth and Disorders、Proteoglycans and glycosaminoglycans research

AIM: To test the hypothesis that K8/K18 variants predispose humans to non-alcoholic fatty liver disease (NAFLD) progression and its metabolic phenotypes. METHODS: We selected a total of 373 unrelated adult subjects from our Physical Examination Department, including 200 unrelated NAFLD patients and 173 controls of both genders and different ages. Diagnoses of NAFLD were established according to ultrasonic signs of fatty liver. All subjects were tested for population characteristics, lipid profile, liver tests, as well as glucose tests. Genomic DNA was obtained from peripheral blood with a DNeasy Tissue Kit. K8/K18 coding regions were analyzed, including 15 exons and exon-intron boundaries. RESULTS: = 0.043). CONCLUSION: K8/K18 variants are overrepresented in Chinese NAFLD patients and might accelerate liver fat storage through IR.