Molybdenum disulfide sphere-based electrochemical aptasensors for protein detection

作者：Honglei Shuai, Xu Wu, Ke‐Jing Huang · 发表于：Journal of Materials Chemistry B · 年份：2017 · DOI：10.1039/c7tb01276d · 被引用次数：51 · 研究领域：Advanced biosensing and bioanalysis techniques、Molecular Junctions and Nanostructures、Electrochemical sensors and biosensors

spheres, signal amplification of the HCR and detection system, and excellent selectivity of the aptamer and sandwich-type strategy, the proposed assay shows a wide linear range of 10 fM-0.1 nM towards thrombin with a detection limit of 27 aM (S/N = 3) along with clear distinction from different proteins. The proposed assay is successfully used to detect thrombin in human serum, which would have promising prospects for disease diagnosis and therapy.