A systematic study of the effect of low pH acid treatment on anti-drug antibodies specific for a domain antibody therapeutic: Impact on drug tolerance, assay sensitivity and post-validation method assessment of ADA in clinical serum samples

作者：Uma Kavita, Jia Duo, Sean M. Crawford, Rong Liu, Joan Valcin, Carol Gleason, Huijin Dong, Snaehal Gadkari, Robert Dodge, Renuka Pillutla, Binodh DeSilva · 发表于：Journal of Immunological Methods · 年份：2017 · DOI：10.1016/j.jim.2017.06.002 · 被引用次数：26 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Biosimilars and Bioanalytical Methods、Protein purification and stability