Relationship between cerebellar structure and emotional memory in depression

作者：Li‐Yan Xu, Fangcheng Xu, Can Liu, Yifu Ji, Jinmin Wu, Ying Wang, Haibao Wang, Yongqiang Yu · 发表于：Brain and Behavior · 年份：2017 · DOI：10.1002/brb3.738 · 被引用次数：50 · 研究领域：Vestibular and auditory disorders、Functional Brain Connectivity Studies、Genetic Neurodegenerative Diseases

Abstract Background A few studies have been conducted on the relationship between cerebellar volume and emotional memory or clinical severity in major depressive disorder (MDD). In this study, we aimed to compare the volume and density of the cerebellar gray matter (GM) in patients with MDD and in healthy controls (HCs) and explore the association between these cerebellar parameters and measurements of emotional memory and clinical severity. Method Voxel‐based morphometry (VBM) and Individual Brain Atlases using Statistical Parametric Mapping (IBASPM) were used to assess GM density and volume in the cerebellum, respectively, in patients with MDD and the HCs. Indicators of emotional memory performance were measured, including the hit rate (HR), rate of false alarm (FA), precision (Pr = HR − FA) and emotional memory enhancement [∆Pr = Pr(emotion) − Pr(neutral)] values. Beck Depression Inventory (BDI) scores were used to measure the severity of depression. Results In the patients with MDD, the GM density was decreased in three cerebellar cortical regions and increased in three cerebellar cortical regions ( p < .005). The GM volumes in eight cerebellar cortical regions were significantly smaller in the patients with MDD than in the HC subjects ( p < .05). In the patients with MDD, the GM volume was correlated with the ∆Pr ( p < .05) in two cerebellar cortical regions. The BDI scores were significantly correlated with the relative GM densities ( p < .05) in 5 cerebella...