Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

作者：Cecilie Morland, Krister A. Andersson, Øyvind P. Haugen, Alena Hadzic, Liv Kleppa, Andreas Gille, Johanne Egge Rinholm, Vuk Palibrk, Elisabeth Holm Diget, Lauritz Hagen Kennedy, Tomas Stølen, Eivind Hennestad, Olve Moldestad, Yiqing Cai, Maja Amedjkouh Puchades, Stefan Offermanns, Koen Vervaeke, Magnar Bjørås, Ulrik Wisløff, Jon Storm‐Mathisen, Linda Hildegard Bergersen · 发表于：Nature Communications · 年份：2017 · DOI：10.1038/ncomms15557 · 被引用次数：562 · 研究领域：Barrier Structure and Function Studies、Neuroinflammation and Neurodegeneration Mechanisms、Neurological Disease Mechanisms and Treatments

Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-like cells along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) and cerebral angiogenesis. High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle shows no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. Thus, we demonstrate that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor.