Macrophages are targets of retinoic acid signaling during the wound-healing process after thulium laser resection of the prostate

作者：Dian‐Jun Yu, Xingjie Wang, Yunfeng Shi, Chenyi Jiang, Ruizhe Zhao, Yiping Zhu, Li Chen, Yuanqing Yang, Xiaowen Sun, Shujie Xia · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.18238 · 被引用次数：5 · 研究领域：Wound Healing and Treatments、Skin Protection and Aging、Urinary Bladder and Prostate Research

// Dian-Jun Yu 1, 4, * , Xing-Jie Wang 2, * , Yun-Feng Shi 1, 5, * , Chen-Yi Jiang 2 , Rui-Zhe Zhao 2 , Yi-Ping Zhu 2 , Li Chen 4 , Yuan-Qing Yang 4 , Xiao-Wen Sun 1, 2, 3 and Shu-Jie Xia 1, 2, 3 1 Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China 2 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China 3 Institute of Urology, Shanghai Jiao Tong University, Shanghai 200080, China 4 Department of Urology, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo 315048, China 5 Department of Urology, Wujin Hospital Affiliated Jiang Su University, Changzhou 213302, China * These authors contributed equally to this work Correspondence to: Shu-Jie Xia, email: xsjurologist@163.com Xiao-Wen Sun, email: sunxiaow1973@163.com Yuan-Qing Yang, email: easternurology@163.com Keywords: benign prostatic hyperplasia, wound healing, retinoic acid, RARβ, macrophage Received: March 13, 2017      Accepted: May 10, 2017      Published: May 26, 2017 ABSTRACT BACKGROUND: The wound-healing process is very important for reducing complications after thulium laser resection of the prostate (TmLRP). The retinoic acid (RA) signaling pathway has been well studied in the wound-healing process of the skin and other organs. The goals of this study were to identify the role of RA signaling in the repair of the prostate after TmLRP and to i...