Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium

作者：Esther Walton, Derrek P. Hibar, Theo G.M. van Erp, Steven G. Potkin, Roberto Roiz‐Santiáñez, Benedicto Crespo‐Facorro, Paula Suárez‐Pinilla, Neeltje E.M. van Haren, Sonja M. C. de Zwarte, René S. Kahn, Wiepke Cahn, Nhat Trung Doan, Kjetil Nordbø Jørgensen, Tiril Pedersen Gurholt, Ingrid Agartz, Ole A. Andreassen, Lars Tjelta Westlye, Ingrid S. Melle, Akiah Ottesen Berg, Lynn Egeland Mørch-Johnsen, Ann Færden, Lena Flyckt, Helena Fatouros‐Bergman, Erik Gunnar Jönsson, Ryota Hashimoto, Hidenaga Yamamori, Masaki Fukunaga, Neda Jahanshad, Pietro De Rossi, Fabrizio Piras, Nerisa Banaj, Gianfranco Spalletta, Raquel E. Gur, Ruben C. Gur, Daniel H. Wolf, Theodore Daniel Satterthwaite, Lauren M. Beard, Iris E. Sommer, Sanne Koops, Oliver Gruber, Anja Richter, Bernd Krämer, Sinéad Kelly, Gary J Donohoe, Colm McDonald, Dara M. Cannon, Aiden P. Corvin, Michael Gill, Annabella Di Giorgio, Alessandro Bertolino, Stephen M. Lawrie, Thomas E. Nickson, Heather Clare Whalley, Emma Neilson, Vince D. Calhoun, Paul M. Thompson, Jessica A. Turner, Stefan Ehrlich · 发表于：Psychological Medicine · 年份：2017 · DOI：10.1017/s0033291717001283 · 被引用次数：180 · 研究领域：Schizophrenia research and treatment、Functional Brain Connectivity Studies、Neurotransmitter Receptor Influence on Behavior

BACKGROUND: Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. Research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (MOFC)], are linked to negative symptoms. Here we tested the hypothesis that MOFC thickness is associated with negative symptom severity. METHODS: This study included 1985 individuals with schizophrenia from 17 research groups around the world contributing to the ENIGMA Schizophrenia Working Group. Cortical thickness values were obtained from T1-weighted structural brain scans using FreeSurfer. A meta-analysis across sites was conducted over effect sizes from a model predicting cortical thickness by negative symptom score (harmonized Scale for the Assessment of Negative Symptoms or Positive and Negative Syndrome Scale scores). RESULTS: Meta-analytical results showed that left, but not right, MOFC thickness was significantly associated with negative symptom severity (β std = -0.075; p = 0.019) after accounting for age, gender, and site. This effect remained significant (p = 0.036) in a model including overall illness severity. Covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left MOFC thickness. As part of a secondary analysis...