CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies

作者：Diogo Gomes‐Silva, Madhuwanti Srinivasan, Sandhya Sharma, Ciaran M. Lee, Dimitrios L. Wagner, Timothy Davis, Rayne H. Rouce, Gang Bao, Malcolm K. Brenner, Maksim Mamonkin · 发表于：Blood · 年份：2017 · DOI：10.1182/blood-2017-01-761320 · 被引用次数：473 · 研究领域：CAR-T cell therapy research、Virus-based gene therapy research、Viral Infectious Diseases and Gene Expression in Insects

) T and NK lymphocytes, we show that the CD7-edited T cells themselves can respond to viral peptides and therefore could be protective against pathogens. Hence, genomic disruption of a target antigen overcomes fratricide of CAR T cells and establishes the feasibility of using CD7 CAR T cells for the targeted therapy of T-cell malignancies.