Prognostic value and preoperative predictors of microvascular invasion in solitary hepatocellular carcinoma ≤ 5 cm without macrovascular invasion

作者：Hui Zhao, Hua Ye, Zhihua Lu, Shen Gu, Laifa Zhu, Yuan Ji, Yudong Qiu, Tu Dai, Huihan Jin · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.18049 · 被引用次数：36 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Cancer Mechanisms and Therapy、Cholangiocarcinoma and Gallbladder Cancer Studies

// Hui Zhao 1, 3, * , Ye Hua 2, * , Zhihua Lu 1 , Shen Gu 3 , Laifa Zhu 1 , Yuan Ji 1 , Yudong Qiu 3 , Tu Dai 1 and Huihan Jin 1 1 Department of Hepatopancreatobiliary Surgery, Nanjing Medical University Affiliated Wuxi Second People’s Hospital, Wuxi, Jiangsu, China 2 Department of Neurology, Nanjing Medical University Affiliated Wuxi Second People’s Hospital, Wuxi, Jiangsu, China 3 Department of Hepatopancreatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China * These authors have contributed equally to this work Correspondence to: Huihan Jin, email: 18762806797@163.com Tu Dai, email: 45687061@qq.com Keywords: hepatocellular carcinoma, microvascular invasion, prognosis, preoperative predictors Received: December 15, 2016      Accepted: April 25, 2017      Published: May 22, 2017 ABSTRACT Objectives: The aim of this study was to investigate the prognostic value and preoperative predictors of microvascular invasion (MVI) in solitary hepatocellular carcinoma (HCC) ≤ 5 cm without macrovascular invasion. Methods: A total of 233 consecutive HCC patients underwent curative hepatectomy were included in our study. Independent risk factors influencing the prognosis were identified, and preoperative predictors for MVI were determined. Results: Multivariate regression analysis identified ICG-R15, BCLC staging and MVI as independent risk factors for the overall ...