Beneficial effect of fluoxetine treatment aganist psychological stress is mediated by increasing BDNF expression in selected brain areas

作者：Gongying Li, Jing Ping, Zhidong Liu, Zhiruo Li, Hongxia Ma, Wenzhen Tu, Wei Zhang, Chuanjun Zhuo · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.17891 · 被引用次数：22 · 研究领域：Nerve injury and regeneration、Stress Responses and Cortisol、Neurogenesis and neuroplasticity mechanisms

// Gongying Li 1, * , Ping Jing 2, * , Zhidong Liu 3, * , Zhiruo Li 4 , Hongxia Ma 5 , Wenzhen Tu 2, # , Wei Zhang 2, # and Chuanjun Zhuo 2, 1, 6, 7, # 1 Insitute of Mental health, Jining Medical University, Jining, 272067, China 2 Department of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou, Zhejiang Province, 325000, China 3 Tianjin Fourth Central Hospital of Tianjin Medical University, Tianjin, 300000, China 4 Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining, 272000, China 5 Department of Psychiatry, The Second Affiliated Hospital of Jining Medical University, Jining, 272051, China 6 Department of Psychiatric Neuroimaging Laboratory, Tianjin Anding Hospital, Tianjin Mental Health Center, Tianjin 300222, China 7 Department of Psychiatry, Tianjin Anning Hospital, Tianjin 300300, China * These authors have contributed equally to this work # Co First authors Correspondence to: Chuanjun Zhuo, email: chuanjunzhuotjmh@163.com Keywords: brain-derived neurotrophic factor (BDNF), psychological stress, fluoxetine, serotonin Received: January 23, 2017      Accepted: April 29, 2017      Published: May 15, 2017 ABSTRACT SSRI antidepressant fluoxetine is widely used to treat psychological stress related disorders, however the underlying working mechanisms is not fully understood, as SSRIs can rapidly increase the extracellular serotonin levels but it normally takes weeks to reveal their t...