Determination of the absolute configuration of compounds bearing chiral quaternary carbon centers using the crystalline sponge method

作者：Shiho Sairenji, Takashi Kikuchi, Mohamed Ahmed Abozeid, Shinobu Takizawa, Hiroaki Sasai, Yuichiro Ando, Kohsuke Ohmatsu, Takashi Ooi, Makoto Fujita · 发表于：Chemical Science · 年份：2017 · DOI：10.1039/c7sc01524k · 被引用次数：40 · 研究领域：Molecular spectroscopy and chirality、Crystallography and molecular interactions、Analytical Chemistry and Chromatography

Determination of the absolute configuration of chiral tetra-substituted carbon centers is one of the most taxing steps in the enantioselective construction of this structural motif in asymmetric synthesis. Here, we demonstrate that the crystalline sponge method provides an effective way to crystallographically determine the absolute configuration of organic compounds bearing chiral quaternary carbons (including tetra-substituted ones) that are synthesized by recently developed enantioselective catalytic reactions.