Enhancer-Derived RNA: A Primer

作者：Feng Liu · 发表于：Genomics Proteomics & Bioinformatics · 年份：2017 · DOI：10.1016/j.gpb.2016.12.006 · 被引用次数：68 · 研究领域：Genomics and Chromatin Dynamics、RNA modifications and cancer、RNA Research and Splicing

Enhancer-derived RNAs (eRNAs) are a group of RNAs transcribed by RNA polymerase II from the domain of transcription enhancers, a major type of cis-regulatory elements in the genome. The correlation between eRNA production and enhancer activity has stimulated studies on the potential role of eRNAs in transcriptional regulation. Additionally, eRNA has also served as a marker for global identification of enhancers. Here I review the brief history and fascinating properties of eRNAs.