Bisphenol A exposure promotes HTR-8/SVneo cell migration and impairs mouse placentation involving upregulation of integrin-β1 and MMP-9 and stimulation of MAPK and PI3K signaling pathways

作者：Xi Lan, Lijuan Fu, Jun Zhang, Xueqing Liu, Huijie Zhang, Xue Zhang, Mingfu Ma, Xuemei Chen, Junlin He, Lianbing Li, Yingxiong Wang, Yubin Ding · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.17882 · 被引用次数：51 · 研究领域：Effects and risks of endocrine disrupting chemicals

// Xi Lan 1 , Li-Juan Fu 1, 2 , Jun Zhang 3 , Xue-Qing Liu 1 , Hui-Jie Zhang 4 , Xue Zhang 1 , Ming-Fu Ma 5 , Xue-Mei Chen 1 , Jun-Lin He 1 , Lian-Bing Li 5 , Ying-Xiong Wang 1 and Yu-Bin Ding 1 1 Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing, 400016, P.R. China 2 Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA 3 Center of Molecular Diagnostic Medicine, Life Science Institute, Chongqing Medical University, Chongqing, 400016, P.R. China 4 Ministry of Education Key Laboratory of Diagnostic Medicine, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, P.R. China 5 The Key Laboratory of Birth Defects and Reproductive Health of the National Health and Family Planning Commission, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, 401147, P.R. China Correspondence to: Yu-Bin Ding, email: 178384198@qq.com Keywords: bisphenol A, extravillous trophoblasts, cell migration, placentation, MAPK/PI3K signaling pathway Received: September 28, 2016     Accepted: April 19, 2017     Published: May 16, 2017 ABSTRACT In this study, we investigated the effect of Bisphenol A (BPA), an endocrine-disrupting chemical, on the migration of human trophoblasts and mouse placentation by using the primary extravillous trophoblast (EVT) and its cell line HTR-8/SVneo, villous explant ...