IL13RA2 targeted alpha particle therapy against glioblastomas

作者：Anirudh Sattiraju, Kiran Kumar Solingapuram Sai, Ang Xuan, Darpan N. Pandya, Frankis G. Almaguel, Thaddeus J. Wadas, Denise Herpai, Waldemar Debinski, Akiva Mintz · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.17792 · 被引用次数：90 · 研究领域：Immunotherapy and Immune Responses、Radiopharmaceutical Chemistry and Applications、RNA Interference and Gene Delivery

// Anirudh Sattiraju 1, 2, * , Kiran Kumar Solingapuram Sai 1, 2, * , Ang Xuan 4, * , Darpan N. Pandya 2 , Frankis G. Almaguel 1 , Thaddeus J. Wadas 1, 3 , Denise M. Herpai 2, 3 , Waldemar Debinski 2, 3 and Akiva Mintz 1, 2 1 Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA 2 Brain Tumor Center of Excellence, Wake Forest University Comprehensive Cancer Center, Winston-Salem, NC 27157, USA 3 Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA 4 Department of Nuclear Medicine and Radiology, The People’s Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China * These authors contributed equally to this work Correspondence to: Akiva Mintz, email: amintz@wakehealth.edu Keywords: glioblastoma, IL13RA2, alpha particle therapy, Actinium-225, Copper-64 Received: January 10, 2017      Accepted: April 15, 2017      Published: May 11, 2017 ABSTRACT Glioblastoma (GBM) is the most aggressive primary malignant brain cancer that invariably results in a dismal prognosis. Chemotherapy and radiotherapy have not been completely effective as standard treatment options for patients due to recurrent disease. We and others have therefore developed molecular strategies to specifically target interleukin 13 receptor alpha 2 (IL13RA2), a GBM restricted receptor expressed abundantly on over 75% of GBM patients. In this work, we evaluated the potential of Pep-1L, a ...