Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL

作者：Sabah Kadri, Jimmy Lee, Carrie Fitzpatrick, Natalie Galanina, Madina Sukhanova, Girish Venkataraman, Shruti Sharma, Brad Long, Kristin Petras, Megan Theissen, Mei Ming, Yuri Kobzev, Wenjun Kang, Ailin Guo, Weige Wang, Nifang Niu, Howard Weiner, Michael J. Thirman, Wendy Stock, Sonali M. Smith, Chadi Nabhan, Jeremy P. Segal, Pin Lu, Y. Lynn Wang · 发表于：Blood Advances · 年份：2017 · DOI：10.1182/bloodadvances.2016003632 · 被引用次数：133 · 研究领域：Chronic Lymphocytic Leukemia Research、Immunodeficiency and Autoimmune Disorders、Lymphoma Diagnosis and Treatment

mutation from that in the CLL leukemia cells. Collectively, these results provide insights into clonal evolution underlying ibrutinib relapse and prompt further investigation on genomic abnormalities that have clinical application potential.