A Robust Framework for Microbial Archaeology

作者：Christina Warinner, Alexander Herbig, Allison E. Mann, James A. Fellows Yates, Clemens L. Weiß, Hernán A. Burbano, Ludovic Orlando, Johannes Krause · 发表于：Annual Review of Genomics and Human Genetics · 年份：2017 · DOI：10.1146/annurev-genom-091416-035526 · 被引用次数：219 · 研究领域：Paleopathology and ancient diseases、Forensic and Genetic Research、Yersinia bacterium, plague, ectoparasites research

Microbial archaeology is flourishing in the era of high-throughput sequencing, revealing the agents behind devastating historical plagues, identifying the cryptic movements of pathogens in prehistory, and reconstructing the ancestral microbiota of humans. Here, we introduce the fundamental concepts and theoretical framework of the discipline, then discuss applied methodologies for pathogen identification and microbiome characterization from archaeological samples. We give special attention to the process of identifying, validating, and authenticating ancient microbes using high-throughput DNA sequencing data. Finally, we outline standards and precautions to guide future research in the field.