Correlation between gyrA and CmeR Box Polymorphism and Fluoroquinolone Resistance in Campylobacter jejuni Isolates in China

作者：Téngfēi Zhāng, Yiluo Cheng, Qingping Luo, Qin Lu, Jun Dong, Rongrong Zhang, Guoyuan Wen, Honglin Wang, Ling Luo, Hongcai Wang, Guoping Liu, Huabin Shao · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2017 · DOI：10.1128/aac.00422-17 · 被引用次数：15 · 研究领域：Salmonella and Campylobacter epidemiology、Antibiotic Resistance in Bacteria、Bacteriophages and microbial interactions

ABSTRACT Sequence analysis of 79 ciprofloxacin-resistant Campylobacter jejuni isolates collected in China showed resistance-related sequence variations in gyrA and CmeR-Box. All the isolates contain an identical Thr-86-Ile substitution in GyrA. Several novel CmeR-Box variations, including point substitutions, deletion, and insertion, were identified. The point insertion or deletion led to dramatically reduced binding of CmeR to the cmeABC promoter, which significantly increases the expression of cmeABC and contributes to the high fluoroquinolone resistance.