Vitamin D and rheumatoid arthritis: an ongoing mystery

作者：Nicola Luigi Bragazzi, Abdulla Ebrahem Watad, Shana G. Neumann, Michael A. Simon, Stav Brown, Arsalan Abu‐Much, Adam Harari, Shmuel Tiosano, Howard Amital, Yehuda Shoenfeld · 发表于：Current Opinion in Rheumatology · 年份：2017 · DOI：10.1097/bor.0000000000000397 · 被引用次数：50 · 研究领域：Vitamin D Research Studies、Biomarkers in Disease Mechanisms、Biotin and Related Studies

PURPOSE OF REVIEW: In recent years, there has been a growing interest in the value of vitamin D and its effects on autoimmunity. The aim of this review is to summarize the current knowledge on the association between vitamin D and rheumatoid arthritis (RA) in terms of prevalence, disease activity, clinical expression, serology and gene polymorphisms of vitamin D receptors. RECENT FINDINGS: Studies have shown contrasting findings concerning the association between vitamin D levels and RA. Vitamin D seems to have immunomodulatory properties. Therefore, low vitamin D levels could contribute to increased immune activation. However, the potential role of vitamin D supplementation in preventing RA manifestation and its beneficial role as a component of RA treatment remain controversial. The relationship between RA susceptibility and vitamin D polymorphisms is also unclear. SUMMARY: Despite advancements synthesized by some recent meta-analyses, the relationship between vitamin D and RA requires further evaluation. Further research is needed to confirm the relationship between RA susceptibility and vitamin D polymorphisms and to determine whether vitamin D plays a role in preventing the manifestation of RA. Finally, additional studies are required to determine the impact and optimal amount of vitamin D supplementation in the treatment of RA patients.