Human cytomegalovirus immediate-early protein promotes survival of glioma cells through interacting and acetylating ATF5

作者：Ming Hu, Bin Wang, Dongmeng Qian, Mengyuan Wang, Rui Huang, Wei Li, Ling Li, Li Zhang, David X. Liu · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.17150 · 被引用次数：19 · 研究领域：Cytomegalovirus and herpesvirus research、Virus-based gene therapy research、RNA regulation and disease

// Ming Hu 1 , Bin Wang 1 , Dongmeng Qian 1 , Mengyuan Wang 2 , Rui Huang 1 , Li Wei 3 , Ling Li 1 , Li Zhang 1 , David X. Liu 4 1 Department of Basic Medical Sciences, Qingdao University, Qingdao, China 2 College of Life Sciences, Qingdao University, Qingdao, China 3 The Hospital of People’s Liberation Army, Weifang, China 4 Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA, USA Correspondence to: Bin Wang, email: humcnn@gmail.com Keywords: HCMV, IE86, glioma, ATF5, acetylation Received: March 08, 2017      Accepted: April 03, 2017      Published: April 17, 2017 ABSTRACT Human cytomegalovirus (HCMV), a widespread beta-herpes virus, infects a high percentage of gliomas. HCMV is specifically detected in human gliomas at a low level of expression raises the possibility that it may regulate the malignant phenotype in a chronic manner. Although HCMV is not recognized as an oncogenic virus, it might dysregulate signaling pathways involved in initiation and promotion of malignancy. Here, our immunohistochemical staining reveals that nucleus staining of the HCMV 86-kDa immediate-early protein (IE86) is markedly increased in GBM (58.56%) compared with that in nontumorous samples (4.20%) and low-grade glioma(19.56%). IE86 staining positively correlates with the staining of activating transcription factor 5 (ATF5) which is essential for glioma cell viability and proliferation sugge...