Mitochondria chaperone GRP75 moonlighting as a cell cycle controller to derail endocytosis provides an opportunity for nanomicrosphere intracellular delivery

作者：Zhihui Gao, Xiuran Niu, Qing Zhang, Hang Chen, Aiai Gao, Shanshan Qi, Rong Xiang, Mattias Belting, Sihe Zhang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.17234 · 被引用次数：24 · 研究领域：Endoplasmic Reticulum Stress and Disease、Lipid Membrane Structure and Behavior、Nanoparticle-Based Drug Delivery

// Zhihui Gao 1, * , Xiuran Niu 1, * , Qing Zhang 2, * , Hang Chen 1 , Aiai Gao 1 , Shanshan Qi 1 , Rong Xiang 1 , Mattias Belting 3 and Sihe Zhang 1 1 Department of Biochemistry & Cell Biology, School of Medicine, Nankai University, Tianjin, China 2 Department of Clinical Laboratory, Cancer Hospital of Tianjin Medical University, Tianjin, China 3 Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden * These authors have contributed equally to this work Correspondence to: Sihe Zhang, email: sihezhang@nankai.edu.cn Keywords: GRP75, cell cycle, clathrin-mediated endocytosis, clathrin-independent endocytosis, nanomicrosphere Received: February 06, 2017     Accepted: March 27, 2017     Published: April 19, 2017 ABSTRACT Understanding how cancer cells regulate endocytosis during the cell cycle could lead us to capitalize this event pharmacologically. Although certain endocytosis pathways are attenuated during mitosis, the endocytosis shift and regulation during the cell cycle have not been well clarified. The conventional concept of glucose-regulated proteins (GRPs) as protein folding chaperones was updated by discoveries that translocated GRPs assume moonlighting functions that modify the immune response, regulate viral release, and control intracellular trafficking. In this study, GRP75, a mitochondria matrix chaperone, was discovered to be highly expressed in mitotic cancer cells. Using synchronized cell ...