GLUT1-mediated selective tumor targeting with fluorine containing platinum(II) glycoconjugates

作者：Ran Liu, Zheng Fu, Meng Zhao, Xiangqian Gao, Hong Li, Qian Mi, Pengxing Liu, Jinna Yang, Zhi Yao, Qingzhi Gao · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.17073 · 被引用次数：33 · 研究领域：Cancer, Hypoxia, and Metabolism、Cancer Research and Treatments、Nanoplatforms for cancer theranostics

// Ran Liu 1 , Zheng Fu 2 , Meng Zhao 3 , Xiangqian Gao 1 , Hong Li 4 , Qian Mi 1 , Pengxing Liu 1 , Jinna Yang 5 , Zhi Yao 2 and Qingzhi Gao 1 1 Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China 2 Department of Immunology, Laboratory of Immune Micro-environment, Tianjin Medical University, Tianjin 300070, P. R. China 3 Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300040, P. R. China 4 Affiliated Hospital, Logistics University of the Chinese People’s Armed Police Force, Tianjin 300162, P. R. China 5 Department of Medicinal Chemistry, Gudui BioPharma Technology Inc., Huayuan Industrial Park, Tianjin 300384, P. R. China Correspondence to: Qingzhi Gao, email: qingzhi@tju.edu.cn Zhi Yao, email: yaozhi@tijmu.edu.cn Keywords: fluorine containing platinum(II) glycoconjugates, glucose transporter 1, Warburg effect, tumor targeting Received: December 20, 2016      Accepted: March 22, 2017      Published: April 13, 2017 ABSTRACT Increased glycolysis and overexpression of glucose transporters (GLUTs) are physiological characteristics of human malig...