RNA-binding protein RBM14 regulates dissociation and association of non-homologous end joining proteins

作者：Nicholas W. Simon, Ming Yuan, Mihoko Kai · 发表于：Cell Cycle · 年份：2017 · DOI：10.1080/15384101.2017.1317419 · 被引用次数：43 · 研究领域：RNA Research and Splicing、RNA modifications and cancer、RNA regulation and disease

Defects in the DNA damage response (DDR) are associated with multiple diseases, including cancers and neurodegenerative disorders. Emerging evidence indicates involvement of RNA-binding proteins (RBPs) in DDR. However, functions of RBPs in the DDR pathway remain elusive. We have shown previously that the RNA-binding protein RBM14 is required for non-homologous end joining (NHEJ). Here we show that RBM14 is required for efficient recruitment of XRCC4 and XLF to chromatin and the release of KU proteins from chromatin upon DNA damage. Failure of this process leads to accumulation of double-strand breaks (DSBs) in cells. Thus RBM14 plays crucial role in regulation of NHEJ upon DNA damage.