Sequestration of Guest Intermediates by Dalesconol Bioassembly Lines in Daldinia eschscholzii

作者：Ai Hua Zhang, Wen Liu, Nan Jiang, Xin Lei Wang, Gang Wang, Qiang Xu, Ren Xiang Tan · 发表于：Organic Letters · 年份：2017 · DOI：10.1021/acs.orglett.7b00786 · 被引用次数：17 · 研究领域：Natural product bioactivities and synthesis、Microbial Natural Products and Biosynthesis、Phytochemistry and Biological Activities

Microbial constructions of secondary metabolites are generally biosynthetic gene cluster (BGC)-based, and the forging of different BGC-sourced intermediates tends to be overlooked. Here, we show that the dalesconol bioassembly lines in Daldinia eschscholzii can sequester guest intermediates (i.e., building blocks produced outside the dalesconol biosynthetic gene cluster) to form arrays of skeletally undescribed molecules such as (+)-dalescone A, a potent inhibitor against the NLRP3 inflammasome activation.