Intercalated 2D nanoclay for emerging drug delivery in cancer therapy

作者：Yi Zhang, Mei Long, Peng Huang, Huaming Yang, Shi Chang, Yuehua Hu, Aidong Tang, Linfeng Mao · 发表于：Nano Research · 年份：2017 · DOI：10.1007/s12274-017-1466-x · 被引用次数：136 · 研究领域：Clay minerals and soil interactions、Therapeutic Uses of Natural Elements、Soil and Unsaturated Flow

Natural two-dimensional (2D) kaolinite nanoclay has been incorporated into an emerging drug delivery system. The basal spacing of the kaolinite nanoclay was expanded from 0.72 to 4.16 nm through the intercalation of various organic guest species of different chain lengths, which can increase the efficiency in drug delivery and reduce the toxicity of doxorubicin (DOX). Original kaolinite (Kaolin) and the Kaolin intercalation compounds exhibited a high level of biocompatibility and very low toxicity towards cells of pancreatic cancer, gastric cancer, prostate cancer, breast cancer, colorectal cancer, esophageal cancer, and differentiated thyroid cancer. However, lung cancer and hepatocellular cancer cells need more strict compositional, structural, and morphological modulations for drug delivery carriers. DOX-Kaolin and the DOX-Kaolin intercalation compounds showed dramatically faster drug release in moderately acidic solution than in neutral condition, and exhibited enhanced therapeutic effects against ten model cancer cell cultures in a dose-dependent manner. The use of 2D nanoclay materials for a novel drug delivery system could feasibly pave a way towards high-performance nanotherapeutics, with superior antitumor efficacy and significantly reduced side effects.