IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC

作者：Leong‐Perng Chan, Cheng Liu, Feng‐Yu Chiang, Ling‐Feng Wang, Ka‐Wo Lee, Wan‐Ting Chen, Po‐Lin Kuo, Chia‐Hua Liang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.16914 · 被引用次数：97 · 研究领域：NF-κB Signaling Pathways、Chemokine receptors and signaling、Immune Response and Inflammation

// Leong-Perng Chan 1, 2 , Cheng Liu 3, 4 , Feng-Yu Chiang 2 , Ling-Feng Wang 2 , Ka-Wo Lee 2 , Wan-Ting Chen 5 , Po-Lin Kuo 1, 6 and Chia-Hua Liang 5 1 Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 2 Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan 3 Division of Plastic Surgery & HBOT Center, Chi Mei Medical Center, Tainan, Taiwan 4 Department of Electrical Engineering, Southern Taiwan University of Science & Technology, Tainan, Taiwan 5 Department of Cosmetic Science and Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Taiwan 6 Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung, Taiwan Correspondence to: Po-Lin Kuo, email: kuopolin@seed.net.tw Chia-Hua Liang, email: tinna_ling@mail.cnu.edu.tw Keywords: HNSCC, IL-8, inflammation, MAPK Received: November 30, 2016      Accepted: March 08, 2017      Published: April 07, 2017 ABSTRACT This investigation identifies interleukin 8 (IL-8) as the main inflammatory mediator in head and neck squamous cell carcinoma (HNSCC). The expressions of chemokines of IL-8, IL-1β and IL-6 and the cytokines of tumor necrosis factor-α (TNF-α) were higher in HNSCC patient tissues than in non-cancerous matched tissues (NCMT) whereas the expression of IL-10 was lower. IL-8 is m...