Association of Adherence to a Healthy Diet with Cognitive Decline in European and American Older Adults: A Meta-Analysis within the CHANCES Consortium

作者：Agnes A. M. Berendsen, Jae Hee Kang, Ondine van de Rest, Nicole Jankovic, Ellen Kampman, Jessica C. Kiefte–de Jong, Oscar H. Franco, M. Arfan Ikram, Hynek Pikhart, Lena Maria Nilsson, Hermann Brenner, Paolo Boffetta, Snorri Björn Rafnsson, Deborah Gustafson, Andreas Kyrozis, Antonia Trichopoulou, Edith J. M. Feskens, Francine Grodstein, C.P.G.M. de Groot · 发表于：Dementia and Geriatric Cognitive Disorders · 年份：2017 · DOI：10.1159/000464269 · 被引用次数：563 · 研究领域：Nutritional Studies and Diet、Nutrition and Health in Aging、Dementia and Cognitive Impairment Research

AIM: To examine the association between a healthy diet, assessed by the Healthy Diet Indicator (HDI), and cognitive decline in older adults. METHODS: Data from 21,837 participants aged ≥55 years from 3 cohorts (Survey in Europe on Nutrition and the Elderly, a Concerted Action [SENECA], Rotterdam Study [RS], Nurses' Health Study [NHS]) were analyzed. HDI scores were based on intakes of saturated fatty acids, polyunsaturated fatty acids, mono- and disaccharides, protein, cholesterol, fruits and vegetables, and fiber. The Telephone Interview for Cognitive Status in NHS and Mini-Mental State Examination in RS and SENECA were used to assess cognitive function from multiple repeated measures. Using multivariable-adjusted, mixed linear regression, mean differences in annual rates of cognitive decline by HDI quintiles were estimated. RESULTS: Multivariable-adjusted differences in rates in the highest versus the lowest HDI quintile were 0.01 (95% CI -0.01, 0.02) in NHS, 0.00 (95% CI -0.02, 0.01) in RS, and 0.00 (95% CI -0.05, 0.05) in SENECA with a pooled estimate of 0.00 (95% CI -0.01, 0.01), I2 = 0%. CONCLUSIONS: A higher HDI score was not related to reduced rates of cognitive decline in European and American older adults.