Direct Catalytic Asymmetric Reductive Amination of Aliphatic Ketones Utilizing Diphenylmethanamine as Coupling Partner

作者：Haizhou Huang, Yunfei Zhao, Yang Yang, Le Zhou, Mingxin Chang · 发表于：Organic Letters · 年份：2017 · DOI：10.1021/acs.orglett.7b00212 · 被引用次数：42 · 研究领域：Asymmetric Hydrogenation and Catalysis、Synthesis and Catalytic Reactions、Chemical Synthesis and Analysis

The highly efficient direct catalytic reductive amination of ketones with diphenylmethanamine catalyzed by iridium-phosphoramidite complexes is described. As an effective coupling partner, diphenylmethanamine is suitable for a wide range of ketones to provide chiral amines in high yields and enantioselectivity. The chiral monodentate phosphoramidite ligands are tunable and competent to accommodate substrates with different structures.