Over-expression of growth differentiation factor 15 (GDF15) preventing cold ischemia reperfusion (I/R) injury in heart transplantation through Foxo3a signaling

作者：Yixin Zhang, L Moszczyński, Qing Liu, Jifu Jiang, Duo Zhao, Douglas Quan, Tina Mele, Vivian C. McAlister, Anthony M. Jevnikar, Seung Joon Baek, Kexiang Liu, Xiufen Zheng · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.16607 · 被引用次数：60 · 研究领域：GDF15 and Related Biomarkers、Circular RNAs in diseases、MicroRNA in disease regulation

// Yixin Zhang 1, 2 , Lisa A. Moszczynski 2 , Qing Liu 1 , Jifu Jiang 2 , Duo Zhao 1, 2 , Douglas Quan 3, 4, 5 , Tina Mele 3, 5 , Vivian McAlister 3, 4, 5 , Anthony Jevnikar 4, 5, 6, 7 , Seung Joon Baek 8 , Kexiang Liu 1 and Xiufen Zheng 2, 3, 4, 5 1 Department of Cardiovascular Surgery, The Second Hospital, Jilin University, Changchun, China 2 Department of Pathology, Western University, Ontario, Canada 3 Department of Surgery, Western University, Ontario, Canada 4 Lawson Health Research Institute, Ontario, Canada 5 London Health Sciences Centre, Ontario, Canada 6 Department of Medicine, Western University, Ontario, Canada 7 Matthew Mailing Centre, London Health Sciences Centre, Ontario, Canada 8 Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA Correspondence to: Xiufen Zheng, email: xzheng26@uwo.ca Kexiang Liu, email: kxliu64@hotmail.com Keywords: GDF15, ischemia reperfusion injury, heart transplantation, Foxo3a Received: January 10, 2017      Accepted: March 02, 2017      Published: March 27, 2017 ABSTRACT Ischemia reperfusion (I/R) injury which inevitably occurs during heart transplantation is the major factor leading to organ failure and graft rejection. In order to develop new therapies to prevent I/R injury, we used both a murine heart transplantation model with 24 hour cold I/R and an in vitro cell culture system to determine whether growth di...