Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care

作者：Aline Marnef, Sarah Cohen, Gaëlle Legube · 发表于：Journal of Molecular Biology · 年份：2017 · DOI：10.1016/j.jmb.2017.03.024 · 被引用次数：143 · 研究领域：DNA Repair Mechanisms、Genomics and Chromatin Dynamics、CRISPR and Genetic Engineering

For decades, it has been speculated that specific loci on eukaryotic chromosomes are inherently susceptible to breakage. The advent of high-throughput genomic technologies has now paved the way to their identification. A wealth of data suggests that transcriptionally active loci are particularly fragile and that a specific DNA damage response is activated and dedicated to their repair. Here, we review current understanding of the crosstalk between transcription and double-strand break repair, from the reasons underlying the intrinsic fragility of genes to the mechanisms that restore the integrity of damaged transcription units.