Lewis-Base-Catalyzed Asymmetric [3 + 3] Annulation Reaction of Morita–Baylis–Hillman Carbonates: Enantioselective Synthesis of Spirocyclohexenes

作者：Wenjun Yang, Wei Sun, Cheng Zhang, Qijun Wang, Zhenyan Guo, Biming Mao, Jianning Liao, Hongchao Guo · 发表于：ACS Catalysis · 年份：2017 · DOI：10.1021/acscatal.7b00320 · 被引用次数：126 · 研究领域：Asymmetric Synthesis and Catalysis、Synthetic Organic Chemistry Methods、Synthesis and Catalytic Reactions

A Lewis-base-catalyzed enantioselective [3 + 3] annulation reaction of Morita–Baylis–Hillman (MBH) carbonates with α-arylidene pyrazolinones is described, affording the pyrazolone-fused spirocyclohexenes bearing an all-carbon quaternary stereocenter in high yields with good to excellent diastereoselectivities and excellent enantioselectivities.