miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis

作者：Tiantian Wang, Hao Xu, Ming Qi, Sheng Yan, Xingsong Tian · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.16681 · 被引用次数：35 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases、Cancer-related molecular mechanisms research

// Tiantian Wang 1 , Hao Xu 1 , Ming Qi 1 , Sheng Yan 2 and Xingsong Tian 1 1 Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China 2 Department of Neurosurgery, The First Hospital Affiliated to Sun Yat-sen University, Guangzhou, Guangdong, China Correspondence to: Sheng Yan, email: // Xingsong Tian, email: // Keywords : miRNA, invasive thyroid cancer, metastasis, meta-analysis Received : November 18, 2016 Accepted : March 13, 2017 Published : March 29, 2017 Abstract Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. However, differences in methods make comparison of gene profiling data difficult. A meta-analysis of published studies comparing miRNA expression data of invasive thyroid carcinoma with paired non-invasive tumors or normal tissues was performed by searching the literature for “invasion”, “thyroid cancer”, and “miRNA”. This revealed 29 dysregulated miRNAs associated with TC in 16 articles; the presence of invasion was confirmed in each respective article by laboratory research or patient follow-up. Among these miRNAs, miRNA-146b, miRNA-221, and miRNA-222 wer...