E6/E7-P53-POU2F1-CTHRC1 axis promotes cervical cancer metastasis and activates Wnt/PCP pathway

作者：Rong Zhang, Huan Lu, Yuanyuan Lyu, Xiaomei Yang, Linyan Zhu, Guangdong Yang, Pengcheng Jiang, Yuan Re, Weiwei Song, Jinhao Wang, Cancan Zhang, Fei Gu, Tianjiao Luo, Zhi‐Yong Wu, Congjian Xu · 发表于：Scientific Reports · 年份：2017 · DOI：10.1038/srep44744 · 被引用次数：72 · 研究领域：Cervical Cancer and HPV Research、Wnt/β-catenin signaling in development and cancer、Cancer-related molecular mechanisms research

Cervical cancer is an infectious cancer and the most common gynecologic cancer worldwide. E6/E7, the early genes of the high-risk mucosal human papillomavirus type, play key roles in the carcinogenic process of cervical cancer. However, little was known about its roles in modulating tumor microenvironment, particular extracellular matrix (ECM). In this study, we found that E6/E7 could regulate multiple ECM proteins, especially collagen triple helix repeat containing 1 (CTHRC1). CTHRC1 is highly expressed in cervical cancer tissue and serum and closely correlated with clinicopathological parameters. CTHRC1 promotes cervical cancer cell migration and invasion in vitro and metastasis in vivo. E6/E7 regulates the expression of CTHRC1 in cervical cancer by E6/E7-p53-POU2F1 (POU class 2 homeobox 1) axis. Futhermore, CTHRC1 activates Wnt/PCP signaling pathway. Take together, E6/E7-p53-POU2F1-CTHRC1 axis promotes cervical cancer cell invasion and metastasis and may act as a potential therapeutic target for interventions against cervical cancer invasion and metastasis.