A novel biodegradable self-healing hydrogel to induce blood capillary formation

作者：Fu-Yu Hsieh, Lei Tao, Yen Wei, Shan‐hui Hsu · 发表于：NPG Asia Materials · 年份：2017 · DOI：10.1038/am.2017.23 · 被引用次数：137 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Angiogenesis and VEGF in Cancer、Hydrogels: synthesis, properties, applications

A novel chitosan–fibrin (CF) injectable, self-healing hydrogel (modulus ~1.2 kPa) is developed. The CF hydrogel has excellent self-healing properties and induces vascular endothelial cells to form capillary-like structure. The self-healing and angiogenic capacities are associated with the interpenetrating network structure of the hydrogel. The hydrogel degrades ~70% in 2 weeks. Injection of the CF hydrogel alone can promote angiogenesis in the perivitelline space of zebrafish and rescue the blood circulation in ischemic hindlimbs of mice. This biomimetic hydrogel has potential applications in vascular repair.