Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features

作者：Min Fang, Yifeng Tao, Zhimin Liu, Hao Huang, Min Lao, Lingsha Huang, Bo Zhu · 发表于：BioMed Research International · 年份：2017 · DOI：10.1155/2017/8047183 · 被引用次数：8 · 研究领域：Mechanisms of cancer metastasis、Metastasis and carcinoma case studies、Cancer Mechanisms and Therapy

The prognostic value of reduced NM23 expression for gastric cancer (GC) patients is still contradictory. Thus, we conducted a meta-analysis to quantitatively evaluate the association of NM23 expression with GC risk and clinical features by analyzing 27 publications. The result of our meta-analysis indicated that NM23 expression is markedly reduced in gastric cancer tissues (OR = 3.15; 95% CI = 1.97–5.03; P < 0.001 ). Furthermore, NM23 expression was negatively correlated with N stage, TNM stage, and histological grade. However, NM23 expression was not correlated with T stage, lymphatic invasion, vascular invasion, and 5-year overall survival rate. In conclusion, reduced NM23 expression correlated with gastric cancer risk, but its association with GC clinical features remains inconclusive. Therefore, large-scale and well-designed studies, which use uniform antibody and criterion of NM23 positive expression, are required to further validate the role of the NM23 in predicting GC progression.