Key proteins and pathways that regulate lifespan

作者：Haihui Pan, Toren Finkel · 发表于：Journal of Biological Chemistry · 年份：2017 · DOI：10.1074/jbc.r116.771915 · 被引用次数：216 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Adipose Tissue and Metabolism、Sirtuins and Resveratrol in Medicine

Here, we review three sets of key proteins and their corresponding downstream pathways that have been linked to extending lifespan and promoting health span in a wide range of organisms. In particular, we review the biology of the sirtuin family of proteins, the insulin/insulin-like growth factor (IGF) signaling (IIS) pathway, and the mechanistic target of rapamycin (mTOR). Using insights derived from simple model organisms, mice, and humans we discuss how these proteins and pathways may potentially alter the rate of aging. We further describe how knowledge of these pathways may lead to the rational design of small molecules that modulate aging and hence alter the propensity for a host of age-related diseases.