High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin

作者：Zhina Wang, Dan Liu, Bin Yin, Wenyi Ju, Huizhong Qiu, Yi Xiao, Yuan‐Jia Chen, Xiaozhong Peng, Chong-mei Lu · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.15873 · 被引用次数：66 · 研究领域：RNA modifications and cancer、RNA Research and Splicing、Cancer, Hypoxia, and Metabolism

// Zhi-na Wang 1, * , Dan Liu 1, 2, * , Bin Yin 3 , Wen-yi Ju 3 , Hui-zhong Qiu 4 , Yi Xiao 4 , Yuan-jia Chen 1 , Xiao-zhong Peng 3 and Chong-mei Lu 1 1 Department of Gastroenteology and Hepatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China 2 Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China 3 National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 4 Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China * These authors have contributed equally to this work Correspondence to: Chong-mei Lu, email: lcm5788@163.com Xiao-zhong Peng, email: pengxiaozhong@pumc.edu.cn Keywords: polypyrimidine tract-binding protein 1, cortactin, colorectal cancer, splicing, invasion Received: June 13, 2016     Accepted: January 23, 2017     Published: March 03, 2017 ABSTRACT Polypyrimidine tract-binding protein 1 (PTBP1) involving in almost all steps of mRNA regulation including alternative splicing metabolism during tumorigenesis due to its RNA-binding activity. Initially, we found that high expressed PTBP1 and poor prognosis was interrelated in colorectal cancer (CRC) patients with stages II and III CR...