Base-mediated insertion reaction of alkynes into carbon–carbon σ-bonds of ethanones: synthesis of hydroxydienone and chromone derivatives

作者：Fangfang Zhang, Qiyi Yao, Yang Yuan, Murong Xu, Lingkai Kong, Yanzhong Li · 发表于：Organic & Biomolecular Chemistry · 年份：2017 · DOI：10.1039/c7ob00476a · 被引用次数：36 · 研究领域：Synthetic Organic Chemistry Methods、Asymmetric Synthesis and Catalysis、Catalytic Alkyne Reactions

Transition-metal free insertions of alkynes into carbon-carbon σ-bonds of ethanones have been reported. These tandem reactions offer an efficient synthesis of hydroxydienones and multi-substituted chromones. This is the first example of base-promoted insertion reactions of isolated carbon-carbon triple bonds into carbon-carbon σ-bonds with active methylene compounds bearing only one electron-withdrawing group.