Targeting quinolone- and aminocoumarin-resistant bacteria with new gyramide analogs that inhibit DNA gyrase

作者：Katherine A. Hurley, Thiago M. A. Santos, Molly R. Fensterwald, Madhusudan Rajendran, Jared T. Moore, Edward I. Balmond, Brice J. Blahnik, Katherine C. Faulkner, Marie H. Foss, Victoria A. Heinrich, Matthew G. Lammers, Lucas C. Moore, Gregory D. Reynolds, Galen P. Shearn‐Nance, Brian A. Stearns, Zi Yao, Jared T. Shaw, Douglas B. Weibel · 发表于：MedChemComm · 年份：2017 · DOI：10.1039/c7md00012j · 被引用次数：11 · 研究领域：Cancer therapeutics and mechanisms、Antibiotic Resistance in Bacteria、Bioactive Compounds and Antitumor Agents

genes), overexpression of GyrA, GyrB, or GyrA and GyrB together does not suppress the inhibitory effect of the gyramides. These observations support the hypothesis that the gyramides inhibit DNA gyrase using a mechanism that is unique from other known inhibitors.