Densitometric and local histogram based analysis of computed tomography images in patients with idiopathic pulmonary fibrosis

作者：Samuel Y. Ash, Rola Harmouche, Diego Lassala, Julian A. Villalba, Kristoffer Ostridge, River Gunville, Carolyn E. Come, Jorge Onieva Onieva, James C. Ross, Gary M. Hunninghake, Souheil El‐Chemaly, Tracy J. Doyle, Pietro Nardelli, Gonzalo Vegas‐Sánchez‐Ferrero, Hilary J. Goldberg, Iván O. Rosas, Raúl San Jośe Estépar, George R. Washko · 发表于：Respiratory Research · 年份：2017 · DOI：10.1186/s12931-017-0527-8 · 被引用次数：107 · 研究领域：Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、Systemic Sclerosis and Related Diseases、Sarcoidosis and Beryllium Toxicity Research

BACKGROUND: Prior studies of clinical prognostication in idiopathic pulmonary fibrosis (IPF) using computed tomography (CT) have often used subjective analyses or have evaluated quantitative measures in isolation. This study examined associations between both densitometric and local histogram based quantitative CT measurements with pulmonary function test (PFT) parameters and mortality. In addition, this study sought to compare risk prediction scores that incorporate quantitative CT measures with previously described systems. METHODS: Forty six patients with biopsy proven IPF were identified from a registry of patients with interstitial lung disease at Brigham and Women's Hospital in Boston, MA. CT scans for each subject were visually scored using a previously published method. After a semi-automated method was used to segment the lungs from the surrounding tissue, densitometric measurements including the percent high attenuating area, mean lung density, skewness and kurtosis were made for the entirety of each patient's lungs. A separate, automated tool was used to detect and quantify the percent of lung occupied by interstitial lung features. These analyses were used to create clinical and quantitative CT based risk prediction scores, and the performance of these was compared to the performance of clinical and visual analysis based methods. RESULTS: All of the densitometric measures were correlated with forced vital capacity and diffusing capacity, as were the total amount o...