Rh-Catalyzed Asymmetric Hydrogenation of α-Substituted Vinyl Sulfones: An Efficient Approach to Chiral Sulfones

作者：Liyang Shi, Biao Wei, Xuguang Yin, Peng Xue, Hui Lv, Xumu Zhang · 发表于：Organic Letters · 年份：2017 · DOI：10.1021/acs.orglett.6b03845 · 被引用次数：33 · 研究领域：Asymmetric Hydrogenation and Catalysis、Catalysis for Biomass Conversion、Nanomaterials for catalytic reactions

Rh/(S)-(+)-DTBM-Segphos complex catalyzed asymmetric hydrogenation of α-substituted vinyl sulfones has been achieved, furnishing the desired products in high yields and excellent enantioselectivities (>90% yield, up to 99% ee). This method provided an efficient approach to α-substituted chiral sulfones under mild conditions and has potential applications in organic synthesis.