T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow

作者：Arielle Glatman Zaretsky, Christoph Konradt, Fabien Dépis, James B. Wing, Radhika Goenka, Daniela Gomez Atria, Jonathan S. Silver, Sunglim Cho, Amaya I. Wolf, William J. Quinn, Julie B. Engiles, Dorothy Cimino Brown, Daniel Beiting, Jan Erikson, David Allman, Michael P. Cancro, Shimon Sakaguchi, Li‐Fan Lu, Christophe Benoıst, Christopher A. Hunter · 发表于：Cell Reports · 年份：2017 · DOI：10.1016/j.celrep.2017.01.067 · 被引用次数：106 · 研究领域：T-cell and B-cell Immunology、Immune Cell Function and Interaction、Immunotherapy and Immune Responses

cells. Gene expression profiling indicated that BM Treg cells express high levels of Treg effector molecules, and CTLA-4 deletion in these cells resulted in elevated PCs. Furthermore, preservation of Treg cells during systemic infection prevents PC loss, while Treg cell depletion in uninfected mice reduced PC populations. These studies suggest a role for Treg cells in PC biology and provide a potential target for the modulation of PCs during vaccine-induced humoral responses or autoimmunity.