Treatment of hepatocellular carcinoma with portal vein tumor thrombus: advances and challenges

作者：Jinfang Jiang, Yong-cong Lao, Bao‐Hong Yuan, Jun Yin, Xin Liu, Long Chen, Jian‐Hong Zhong · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.15411 · 被引用次数：85 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Endoplasmic Reticulum Stress and Disease、Cancer, Lipids, and Metabolism

// Jin-Fang Jiang 1 , Yong-Cong Lao 1 , Bao-Hong Yuan 2 , Jun Yin 3 , Xin Liu 1 , Long Chen 4 and Jian-Hong Zhong 5 1 Department of Chemotherapy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China 2 Department of General Surgery, Yan’An Hospital Affiliated to Kunming Medical University, Kunming, China 3 Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China 4 Department of Radiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China 5 Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China Correspondence to: Jian-Hong Zhong, email: // Long Chen, email: // Keywords : hepatic resection; hepatocellular carcinoma; portal vein tumor thrombosis; transarterial chemoembolization Received : December 28, 2016 Accepted : February 02, 2017 Published : February 16, 2017 Abstract Portal vein tumor thrombus is a frequent, challenging complication in hepatocellular carcinoma. Hepatocellular carcinoma patients with portal vein tumor thrombus may show worse liver function, less treatment tolerance and worse prognosis than patients without portal vein tumor thrombus, and they may be at higher risk of comorbidity related to portal hypertension. Western and some Asian guidelines stratify hepatocellular carcinoma with portal vein tumor thrombus together with metastatic hepa...