HnRNPK/miR-223/FBXW7 feedback cascade promotes pancreatic cancer cell growth and invasion

作者：De He, Cheng Huang, Qingxin Zhou, Dawei Liu, Longhui Xiong, Hongxia Xiang, Guangnian Ma, Zhiyong Zhang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.15529 · 被引用次数：38 · 研究领域：MicroRNA in disease regulation、RNA modifications and cancer、RNA Research and Splicing

// De He 1, * , Cheng Huang 1, 2, * , Qingxin Zhou 3, * , Dawei Liu 1, 2 , Longhui Xiong 1 , Hongxia Xiang 1 , Guangnian Ma 1 , Zhiyong Zhang 4 1 Department of General Surgery, The Affiliated Baoan Hospital of Southern Medical University, Shenzhen, Guangdong, 518101, China 2 Guangdong Medical University Graduate School, Zhanjiang, Guangdong, 524001, China 3 Department of Gastrointestinal Oncology, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China 4 Department of Surgery, Robert-Wood-Johnson Medical School University Hospital, Rutgers University, New Brunswick, NJ 08901, USA * These authors have contributed equally to this work Correspondence to: Zhiyong Zhang, email: zhangz2@rwjms.rutgers.edu , zhiyongzhng3@gmail.com De He, email: hede1965@126.com Keywords: HnRNPK, miR-223, FBXW7, pancreatic ductal adenocarcinoma, GSK3 Received: July 25, 2016      Accepted: January 23, 2017      Published: February 20, 2017 ABSTRACT Several studies have identified miR-223 critically involved in various types of cancer, including pancreatic ductal adenocarcinoma ( PDAC ). However, its action and regulatory mechanisms in PDAC remains largely unclear. In this study, we found that the expression levels of miR-223 were increased in clinical samples with PDAC (81.6%). The upregulation of miR-223 increases the proliferation, migration, and invasive abilities of PDAC cells in vitro and in vivo . Mechanistically, miR-223...