MicroRNA-143-3p, up-regulated in H. pylori -positive gastric cancer, suppresses tumor growth, migration and invasion by directly targeting AKT2

作者：Fang Wang, Jiatao Liu, Yanfeng Zou, Yang Jiao, Yawei Huang, Lulu Fan, Xiaoqiu Li, Hanqing Yu, Chengqun He, Wei Wei, Hua Wang, Guoping Sun · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.15646 · 被引用次数：62 · 研究领域：MicroRNA in disease regulation、Cancer-related molecular mechanisms research、RNA modifications and cancer

// Fang Wang 1 , Jiatao Liu 1, 2 , Yanfeng Zou 3 , Yang Jiao 1 , Yawei Huang 1 , Lulu Fan 1 , Xiaoqiu Li 1 , Hanqing Yu 1 , Chengqun He 4 , Wei Wei 5 , Hua Wang 1, 6, * , Guoping Sun 1, * 1 Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China 2 Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China 3 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China 4 Department of Gynaecology and Obstetrics, Anhui Provincial Hospital, Hefei 230001, Anhui, China 5 Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, Anhui, China 6 Institute for Liver Diseases of Anhui Medical University, Hefei 230032, Anhui, China * These authors have contributed equally to this work Correspondence to: Hua Wang, email: wanghua@ahmu.edu.cn Guoping Sun, email: sungp@ahmu.edu.cn Keywords: Helicobacter pylori , gastric cancer, microRNA-143-3p, AKT2, progression Received: May 23, 2016     Accepted: January 27, 2017     Published: February 23, 2017 ABSTRACT Our previous studies have suggested a protective role for H. pylori infection in the prognosis of gastric cancer. Based on those findings, we hypothesized that H. pylori -positive and -negative gastric cancers may exhibit different growth patterns and pathobiological behaviors, indicating different mechanisms of cance...