An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma

作者：You Liu, Lian-Tao Sun, Peter Fong, Jie Yang, Zhuxia Zhang, Shuihui Yin, Shuyuan Jiang, Xiaolei Liu, Hongge Ju, Lihua Huang, Jing Bai, Kerui Gong, Shaochun Yan, Chun‐yang Zhang, Guo Shao · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.14966 · 被引用次数：19 · 研究领域：Epigenetics and DNA Methylation、Renal and related cancers、Renal cell carcinoma treatment

// You Liu 1 , Liantao Sun 1 , Peter Fong 2 , Jie Yang 1 , Zhuxia Zhang 1 , Shuihui Yin 1 , Shuyuan Jiang 1 , Xiaolei Liu 1 , Hongge Ju 1 , Lihua Huang 1 , Jing Bai 1 , Kerui Gong 3 , Shaochun Yan 1 , Chunyang Zhang 4 , Guo Shao 1, 5 1 Biomedicine Research Center and Basic Medical College, Baotou Medical College, Inner Mongolia, PRC 2 Department of Neurology, University of California San Francisco, San Francisco, CA, USA 3 Department of Oral and Maxillofacial Surgery, University of California San Francsico, San Francisco, CA, USA 4 Department of Neurology, First Affiliated Hospital of Baotou Medical College, Inner Mongolia, PRC 5 Institute for Hypoxia Medicine, Capital Medical University, Beijing, PRC Correspondence to: Chunyang Zhang, email: zhangchunyangbyyfy@163.com Guo Shao, email: shao_guo_china@163.com Keywords: DNA methyltransferase 3B, clear cell renal cell carcinoma Received: June 07, 2016      Accepted: January 03, 2017      Published: February 01, 2017 ABSTRACT It is well known that abnormal DNA methylations occur frequently in kidney cancer. However, it remains unclear exactly which types of DNA methyltransferases (DNMT) contribute to the pathologies of kidney cancers. In order to determine the functions of DNA methyltransferase in kidney tumorigenesis on the molecular level, we examined the mRNA expression levels of DNMT1, DNMT3A, DNMT3B, and DNMT3B variants in renal cell carcinoma tissue. Both mRNA and protein le...