Comparative study of laparoscopy-assisted and open radical gastrectomy for stage T4a gastric cancer

作者：Fan Zhang, Yuanzhi Lan, Bo Tang, Yingxue Hao, Yan Shi, Peiwu Yu · 发表于：International Journal of Surgery · 年份：2017 · DOI：10.1016/j.ijsu.2017.01.116 · 被引用次数：57 · 研究领域：Gastric Cancer Management and Outcomes、Esophageal Cancer Research and Treatment、Gastrointestinal Tumor Research and Treatment

BACKGROUND: The feasibility and safety of laparoscopic-assisted gastrectomy as a first-line treatment for advanced gastric cancer is controversial, especially for patients with serous membrane invasion. This study was designed to evaluate and compare the clinical effect of laparoscopy-assisted and open radical gastrectomy for stage T4a gastric cancer. MATERIALS AND METHODS: We performed a retrospective analysis of the clinical data of 230 patients with stage T4a gastric cancer in our hospital from October 2006 to October 2008. A total of 111 patients with stage T4a gastric cancer underwent laparoscopic radical gastrectomy (LARG group), and 119 patients with stage T4a gastric cancer underwent open radical gastrectomy (ORG group). Clinical parameters, including incision length, operation time, blood loss, time to first flatus, time to first defecation, length of hospital stay, postoperative complications, one-year, three-year, and five-year disease-free survival rates, and the overall survival rate were analyzed via t-tests and chi-squared tests. RESULTS: The incision length, blood loss, time to first flatus, time to first defecation, and length of hospital stay in the LARG group were significantly less than in the ORG group (P < 0.05). The mean operation time in the LARG group was similar to that in the ORG group (P > 0.05). Postoperative complications were significantly less in the LARG group than in the ORG group (P < 0.05). The one-year, three-year, and five-year disease-fr...