Size-Dependent Ag 2 S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy

作者：Tao Yang, Yongan Tang, Ling Liu, Xiaoyan Lv, Qiaoli Wang, Hengte Ke, Yibin Deng, Hong Liang Yang, Xiangliang Yang, Gang Liu, Yuliang Zhao, Huabing Chen · 发表于：ACS Nano · 年份：2017 · DOI：10.1021/acsnano.6b07866 · 被引用次数：414 · 研究领域：Nanoplatforms for cancer theranostics、Extracellular vesicles in disease、Gold and Silver Nanoparticles Synthesis and Applications

Ag 2 S nanoparticles are increasingly important in biomedicine, such as in cancer imaging. However, there has been only limited success in the exploration of theranostic Ag 2 S nanoparticles for photoinduced cancer imaging and simultaneous therapy. Here we report size-dependent Ag 2 S nanodots (NDs) with well-defined nanostructure as a theranostic agent for multimodal imaging and simultaneous photothermal therapy. The NDs are precisely synthesized through carefully controlled growth of Ag 2 S in hollow human serum albumin nanocages. These NDs produce effective fluorescence in second near-infrared (NIR-II) region, distinct photoacoustic intensity, and good photothermal conversion in a size-dependent manner under light irradiation, thereby generating sufficient in vivo fluorescence and photoacoustic signals as well as potent hyperthermia at tumors. Moreover, Ag 2 S NDs possess ideal resistance to photobleaching, effective cellular uptake, preferable tumor accumulation, and in vivo elimination, thus facilitating NIR-II fluorescence/photoacoustics imaging with both ultrasensitivity and microscopic spatial resolution and simultaneous photothermal tumor ablation. These findings provide insight into the clinical potential of Ag 2 S nanodots for cancer theranostics.