Antibody-secreting plasma cells persist for decades in human intestine

作者：Ole J.B. Landsverk, Omri Snir, Raquel Bartolomé-Casado, Lisa M. Richter, Jeff Eron Mold, Pedro Réu, Rune Horneland, Vemund Paulsen, Sheraz Yaqub, Einar Martin Aandahl, Ole M. Øyen, Hildur Sif Thorarensen, Mehran Salehpour, Göran Possnert, Jonas Frisén, Ludvig Magne Sollid, Espen S. Bækkevold, Frode Lars Jahnsen · 发表于：The Journal of Experimental Medicine · 年份：2017 · DOI：10.1084/jem.20161590 · 被引用次数：259 · 研究领域：T-cell and B-cell Immunology、Complement system in diseases、Immune Cell Function and Interaction

Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19+ PC subset was dynamically exchanged, whereas of two CD19− PC subsets, CD45+ PCs exhibited little and CD45− PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45− PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19− PC subsets support selection and maintenance of protective PCs for life in human intestine.